The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes
K Sahlholm, J Nilsson, D Marcellino, K Fuxe… - European journal of …, 2007 - Elsevier
The histamine H3 receptor mediates inhibitory responses in the nervous system. Here, we
demonstrate the coupling of the human histamine H3 receptor to G protein-coupled inward
rectifier potassium (GIRK) channels in Xenopus oocytes, using voltage-clamp. The
histamine H3 receptor agonist (R)-α-methylhistamine increased GIRK currents with an EC50
of 2.5 nM. The response to (R)-α-methylhistamine was inhibited by the specific
antagonist/inverse agonist clobenpropit. GIRK channels represent a novel effector pathway …
demonstrate the coupling of the human histamine H3 receptor to G protein-coupled inward
rectifier potassium (GIRK) channels in Xenopus oocytes, using voltage-clamp. The
histamine H3 receptor agonist (R)-α-methylhistamine increased GIRK currents with an EC50
of 2.5 nM. The response to (R)-α-methylhistamine was inhibited by the specific
antagonist/inverse agonist clobenpropit. GIRK channels represent a novel effector pathway …
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